Function that allows to assign random values (from the bottom-X percent of the LFQ values distribution) to proteins that show missing values for all the replicates of a specific condition.

randomize.missing.values(DEprot.object, group.column, tail.percentage = 5)

Arguments

DEprot.object

A DEprot object, as generated by load.counts.

group.column

String indicating a column for the metadata table which indicates the IDs of the conditions within which the missing values should be tested.

tail.percentage

Numeric value between 0 and 100 (excluded) indicating the threshold percentage of the distribution from which random values should be sampled. Default: 5 (percent).

Value

A DEprot object in which the completely missing values have been substituted in the normalized counts table.